• There are several investigational protocols in use, including chemotherapy , radiation therapy with neutron beams, or radiation accompanied by anticancer drugs such as doxorubicin , cisplatin , carboplatin , cyclophosphamide and 5-fluorouracil. Treatment by Stage Stage I Standard Treatment • For low-grade tumors, surgery alone. Radiotherapy may be an alternative if surgery would cause significant cosmetic or functional problems. Radiotherapy is also used after surgery if the margins are involved. • For high-grade tumors, surgery alone, although adjuvant radiotherapy may also be given (especially with positive surgical margins). If the tumor cannot be removed, radiotherapy may be used for palliation. If the tumor has spread to the neck lymph nodes , these nodes should be removed. Local recurrence may be reduced by adjuvant radiotherapy. Neutron beam radiation is under clinical evaluation, and recent studies indicate that these tumors may also respond to chemotherapy. Five-Year Survival 90 percent